Mitobridge

An Astellas Company

targeting mitochondria advancing human health

Patients

Mitobridge is committed to developing medicines that improve mitochondrial function and treat challenging diseases. Operating within the Astellas companies, we put patients first – at the forefront of our work, considering what matters most to them, and involving them in our processes. Keeping patients at the center of what we do is key to delivering optimal value to those who are living with the diseases we seek to treat with our medicines.

Below you will find more information about diseases we are targeting and resources for patients.

ASP1128 for Acute Kidney Injury

Disease with unmet need

Acute kidney injury (AKI) is a sudden loss of kidney function that often occurs in hospitalized patients as a result of cardiac and/or vascular surgery or other trauma or infection.

New treatment approach

We are developing ASP1128, a potentially first-in-class investigational medicine for the treatment of AKI. ASP1128 is believed to have protective effects of kidney cells in stressful situations of AKI by promoting fatty acid oxidation in the mitochondria.

Learn more

Clinical trial

A proof of concept Phase 2 clinical study with ASP1128 is ongoing. Information about the trial and participating centers can be found at Clinicaltrials.gov (identifier: NCT03941483).

Resources in the treatment community

National Kidney Foundation Logo

ASP0367 for Duchenne Muscular Dystrophy

Disease with unmet need

Duchenne Muscular Dystrophy (DMD) is a rare genetic disease that causes progressive muscle degeneration and weakness due to alterations of a protein called dystrophin. With onset in early childhood, this debilitating fatal disorder affects primarily boys and leads to progressive cardiac, skeletal and smooth muscle weakness and eventual loss of muscle mass.

New treatment approach

We are developing ASP0367, a mitochondrial-directed investigational medicine for the treatment of DMD, which is designed to treat DMD by increasing fatty acid oxidation and mitochondrial biogenesis in muscle cells.

Learn more

Clinical trial

A Phase 1b clinical study with ASP0367, is scheduled to evaluate safety and efficacy in DMD patients starting in early 2020. Information about the trial and participating centers can be found at Clinicaltrials.gov (identifier: NCT04184882).

Resources in the treatment community

cure duchenne logoJett Foundation logoParent Project Muscular Dystrophy Logo
collaborative trajectory analysis project logotreatnmd neuromuscular network logo

Additional resources for mitochondrial diseases

Mitobridge is applying new scientific insights to develop mitochondrial-targeted medicines for a range of diseases, and we collaborate with members of the patient and treatment community who share this vision.

Mito Action Logo NAMDC logo united mitochondrial disease foundation

up